This study was carried out to evaluate different spraying regimes for the production of two cowpea varieties (Ife Brown and IT2246) in the humid southwest agro-ecologies of Nigeria in order to recommend optimum spraying regimes for cowpea production in the zone. Agronomic data were collected from trials conducted in 2020 and 2021 in outstations representative of the broad agro-ecologies of this region of Nigeria.